In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6959-48-4, name is 3-(Chloromethyl)pyridine hydrochloride, the common compound, a new synthetic route is introduced below. Safety of 3-(Chloromethyl)pyridine hydrochloride
To a stirring solution of 4-(1-tert-Butoxycarbonyl-2-methyl-propylsulfamoyl)-benzoic acid methyl ester (Compound 1*-884 mg, 2.38 mmol) in dimethylformamide (30 ml) at ambient temperature was added cesium carbonate (10.86 g, 33.34 mmol). Then 3-picolyl chloride hydrochloride (546 mg, 3.33 mmol) was added to the suspension and the reaction mixture was stirred at room temperature for 24 hours by which time TLC (EtOAc/Hexane 1:1) monitoring showed the reaction to be completed. The mixture was evaporated to dryness and the residue was stirred in ethyl acetate (50 ml). The ethyl acetate phase was extracted with water (1×50 ml), dried (MgSO4), filtered and evaporated to afford the crude product as a brown oil. This oil was purified by flash chromatography to furnish the pure product as colourless oil. Yield 800 mg (79.21%).
The synthetic route of 6959-48-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Storey, Anthony; Davis, Julie; Ricketts, Sally-Ann; Medizabal, Marivi; Cuthbertson, Alan; Arukwe, Joseph; Heywood, Kirsty; Wilson, Ian; Wynn, Duncan; Schafers, Michael; Levkau, Bodu; Wagner, Stefan; Breyholz, Hans-Jorg; Kopka, Klaus; US2007/71670; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem