Adding a certain compound to certain chemical reactions, such as: 76041-71-9, 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 76041-71-9, blongs to pyridine-derivatives compound. Recommanded Product: 76041-71-9
Preparation of N-({[3-chloro-5-(trifluoromethyl)pyridin-2-ylloxy}methyl)-2- (trifluoromethyl)benzamide (compound 1)To a solution of 0.20Og (1.01 mmol) of 3-chloro-5-(trifluoromethyl)pyridin- 2-ol in 5 ml of a mixture tetrahydofurane/NaOH IM (4/1) was added 0.263g {[2- (trifluoromethyl)benzoyl]amino}methyl acetate (1.01 mmol). The mixture was stirred 14 hours at room temperature.The reaction mixture was poured into 10ml of diethyl ether. Afire separation of the phases, the organic phase was washed twice with 5ml of water and dried over magnesium sulphate.After filtration, the solvent was evaporated and the residue was purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 6/4) to give N-({[3- chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-2-(trifluoromethyl)benzamide: 298 mg (74%). Mass spectrum : 399 (M+ 1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,76041-71-9, 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; BAYER CROPSCIENCE SA; WO2008/3744; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem