Related Products of 778611-64-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 778611-64-6, name is 5-Bromo-2-chloro-4-methylpyridine, molecular formula is C6H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1 : To a solution of BB-3 (100 mg, 0.287 mmol) in toluene (10 mL), K2C03 (119 mg, 0.86 mmol), 5- bromo-2-chloro-4-methylpyridine (77 mg, 0.373 mmol) and Lambda/,/V -dimethyl ethylene diamine (13 mg, 0.143 mmol) were added and the mixture was degassed through purging with Ar for 30 min. Cul (27 mg, 0.14 mmol) was added and the RM was heated to 100C for 48 h. The RM was chilled, diluted with toluene and filtered over a plug of celite. The volatiles were removed under reduced pressure and the residue was purified by flash CC (silica gel, Hex/EtOAc) to yield the desired compound (60 mg, 45%).
According to the analysis of related databases, 778611-64-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GRUeNENTHAL GMBH; VOSS, Felix; RITTER, Stefanie; NORDHOFF, Sonja; WACHTEN, Sebastian; OBERBOeRSCH, Stefan; KLESS, Achim; WO2015/22073; (2015); A1;,
Pyridine – Wikipedia,
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