Reference of 1026201-45-5, Adding some certain compound to certain chemical reactions, such as: 1026201-45-5, name is 8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid,molecular formula is C8H5BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1026201-45-5.
A suspension of intermediate 39 (322 mg, 1.34 mmol) and carbonyldiimidazole (238 mg, 1.47 mmol) in THF (11 ml) was stirred at r.t. for 2 h. DIPEA (0.233 ml, 1.34 mmol) was added and the resulting mixture was stirred for 30 min. at r.t. Then DMF (2 ml) was added to the suspension and the mixture was stirred for 60 h at r.t. The r.m. was cooled to 0 0C and O,N-dimethyl-hydroxylamine (143 mg, 1.47 mmol) was added. The mixture was stirred for 20 h at r.t. The solvents were evaporated under reduced pressure. The residue was dissolved in DCM and washed 3 times with H2O. The organic layer was dried (MgSO4), filtered and evaporated under reduced pressure. The residue was purified via flash column chromatography over silicagel (eluent: DCM/MeOH(NH3) from 100/0 to 99/1). The product fractions were collected and the solvent was evaporated in vacuo. Yield: 216 mg of intermediate 42 (57 %).
According to the analysis of related databases, 1026201-45-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; TRESADERN, Gary, John; TRABANCO-SUAREZ, Andres, Avelino; VAN BRANDT, Sven, Franciscus, Anna; BERTHELOT, Didier, Jean-Claude; WO2010/70008; (2010); A1;,
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