823-56-3, Adding a certain compound to certain chemical reactions, such as: 823-56-3, 2-Fluoro-3,5-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 823-56-3, blongs to pyridine-derivatives compound.
To a mixture of methyl (lr, 4r) -4-hydroxy-2′ -oxo-1′ , 2′ – dihydrospiro [cyclohexane-1, 3′ -indole] -5′ -carboxylate (1.00 g) and tetrahydrofuran (60 ml) was added sodium hydride (60% in oil, 436 mg) at 0C, and the mixture was stirred at the same temperature for 30 min and 3, 5-dichloro-2-fluoropyridine (723 mg) was added. After stirring at room temperature for 8 hr, N, -dimethylformamide (60 ml) was added, and the mixture was further stirred at room temperature for 12 hr. The reaction mixture was poured into ice-cooled water and extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give a white solid. To a mixture of the obtained solid, tetrahydrofuran (20 ml) and water (20 ml) was added lithium hydroxide monphydrate (130 mg) at room temperature, and the mixture was stirred at 50C for 3 hr and concentrated under reduced pressure. The residue was adjusted to pH=3.0 by adding 3N hydrochloric acid and extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (1.00 g)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-56-3, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TERAO, Yoshito; TAKAHASHI, Masashi; HARA, Ryoma; HIDAKA, Kousuke; FURUKAWA, Hodeki; YAMASAKI, Takeski; KASAI, Shizuo; (147 pag.)WO2018/182051; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem