Adding a certain compound to certain chemical reactions, such as: 84539-34-4, 4-Amino-3,5-dibromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4-Amino-3,5-dibromopyridine, blongs to pyridine-derivatives compound. Quality Control of 4-Amino-3,5-dibromopyridine
A sealed reaction vessel charged with 4-amino-3,5-dibromopyridine (643 mg, (0490) 2.55 mmol, 1 equiv) and potassium ethyl xanthogenate (495 mg, 3.09 mmol, 1.21 equiv) in N,N-dimethylacetamide (8.0 mL) was heated with microwave irradiation at 160 C for 20 min. Additional potassium ethyl xanthogenate (0.490 g, 3.06 mmol, 1.20 equiv) was added to the mixture, and the resulting solution was heated with microwave irradiation at 160 C for a further 20 min. The reaction mixture was cooled to 0 C before the addition of iodomethane (382 mu^, 6.13 mmol, 2.40 equiv). After 20 min, the reaction was concentrated in vacuo and the resultant residue purified by flash column chromatography (solvent: 2: 1 heptane / ethyl acetate). Appropriate fractions were combined and evaporated to afford 7-bromo-2-(methylthio)thiazolo[5,4-c]pyridine (505 mg, 75.7%) as a tan solid. 1H NMR (500 MHz, CDC13): delta: 8.88 (s, 1H), 8.66 (s, 1H), 2.85 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,84539-34-4, 4-Amino-3,5-dibromopyridine, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ZAK, Mark; ROMERO, F. Anthony; YUEN, Po-wai; HANAN, Emily J.; (139 pag.)WO2018/166993; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem