In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 847406-13-7, name is Ethyl 1-(5-bromopyridin-3-yl)piperidine-4-carboxylate, the common compound, a new synthetic route is introduced below. SDS of cas: 847406-13-7
To a flask was added 7A (1. 00 G, 3.19 MMOL), DIOXANE (13 ML), triethyl AMINE (0. 97 g, 9. 58 mmol) and pinacol borane (0. 613 G., 4. 79’mmol). The mixture was degassed with N2 for 15 min and Pd2Cl2- (dppf) dcm (0.132 g, 0.16 mmol) was added. The flask was heated to 90C for 12 h and cooled to ambient temperature. The crude product was concen- rated in vacuo and purified by flash chromatography on silica gel eluting with 15% 7N methanolic ammonia/CM to provide the title compound (400 mg, 45%) 1H NMR (DMSO-d6, 400 MHz) 5 8.31 (d, J=2.73 Hz, 1H), 8.09 (m, 1H), 7.18 (m, 2H), 4.16 (dd, J=7.02, 14.04 Hz, 2H), 3.67 (m, 2H), 2. 85 (m, 2H), 2.46 (m, 1H), 2.05 (m, 2H), 1.89 (m, . 2H), 1.28 (t, J=7. 21 HZ,. 3H).
The synthetic route of 847406-13-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ICOS CORPORATION; WO2005/19200; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem