The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 885326-88-5, name is Methyl 6-amino-4-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Methyl 6-amino-4-bromopicolinate
A mixture of Example 106C (644 mg, 2.79 mmol, 1 eq), 2- chloroacetaldehyde (40 % in H20, 1.63 mL, 23.33 eq) and NaHC03 (398 mg, 4.74 mmol, 1.7 eq) in EtOH (10 mL) was heated to 80 C 12 hours. The mixture was cooled to 20 C and basified with aq. Na2C03. The aqueous phase was extracted with ethyl acetate (30 mL*2). The combined organic phase was washed with brine (10 mL*2), dried with anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (gradient 5 to 50% EA in PE). Example 106D (600 mg crude) was obtained as a brown oil and used directly in next step.
With the rapid development of chemical substances, we look forward to future research findings about 885326-88-5.
Reference:
Patent; CHRYSALIS, INC.; GWALTNEY, Stephen; (147 pag.)WO2017/214413; (2017); A1;,
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