Electric Literature of 893444-21-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 893444-21-8, name is 3-Nitro-6-(trifluoromethyl)pyridin-2-amine. A new synthetic method of this compound is introduced below.
To compound 5.2 (138 mg, <0.67 mmol) in methanol / ethyl acetate (10 mL, 1:1) at room temperature was added palladium on carbon (36 mg, 10%, wet) and the reaction mixture was placed under an atmosphere of hydrogen(balloon). After 1.5 hours, the reaction mixture was filtered through a pad of celite and the filter cake was washed with ethyl acetate and methanol. The solvent was removed under reduced pressure to afford diamine 5.3 (149 mg, >100%) as a yellow film, which was used without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,893444-21-8, its application will become more common.
Reference:
Patent; SUNESIS PHARMACEUTICALS, INC.; WO2006/65703; (2006); A1;,
Pyridine – Wikipedia,
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