In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 898746-46-8, name is 1H-Pyrrolo[2,3-b]pyridine-6-carbaldehyde, the common compound, a new synthetic route is introduced below. Product Details of 898746-46-8
To a solution of 1H-pyrrolo[2,3-b]pyridine-6-carbaldehyde (196 mg, 1 .26 mmol) in dichloromethane (4 mL) was added, at 0 C, diethylaminosulfur trifluoride ( 260 mI_, 1 .91 mmol). The reaction mixture was stirred 4h at room temperature. Pour the reaction on a mixture of ice and NaHC03 and extract 3 times with DCM. Dry the organic phase on Na2S04 and concentrate the solvents to get 6-(difluoromethyl)-1H-pyrrolo[2,3-b]pyridine XI-1 (96 mg) as a brown solid (1000) Yield: 45%. (1001) Basic LCMS Method 1 (ES+): 169 (M+H)+, 82% purity.
The synthetic route of 898746-46-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UCB PHARMA GMBH; PEGURIER, Cecile; PROVINS, Laurent; CARDENAS, Alvaro; LEDECQ, Marie; MUELLER, Christa E.; HOCKEMEYER, Joerg; EL-TAYEB, Ali; BOSHTA, Nader; RASHED, Mahmoud; (165 pag.)WO2019/243303; (2019); A1;,
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