Related Products of 918516-27-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.918516-27-5, name is 5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine, molecular formula is C13H9ClN2, molecular weight is 228.68, as common compound, the synthetic route is as follows.
To a suspension of 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine (6b) (100 mg, 0.44 mmol) and N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide (5) (139 mg, 0.53 mmol) in methanol (7.0 mL) was added potassium hydroxide (197 mg, 3.5 mmol). The reaction mixture was stirred at room temperature for 3 d and then evaporated to dryness. The crude reaction mixture was diluted with water (5.0 mL) and the pH adjusted to 7 with 4.0 N hydrochloric acid (10 mL). The resulting mixture was then diluted with water (25 mL) and extracted with ethyl acetate (3 x 20 mL). The combined organic layers were dried over sodium sulphate and evaporated in vacuo to give a crude solid (as a 2:1 mixture of the -OMe and free-OH 7b).
The chemical industry reduces the impact on the environment during synthesis 918516-27-5, I believe this compound will play a more active role in future production and life.
Reference:
Article; Buck, Jason R.; Saleh, Sam; Imam Uddin, Md.; Manning, H. Charles; Tetrahedron Letters; vol. 53; 32; (2012); p. 4161 – 4165;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem