The origin of a common compound about 926293-55-2

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 926293-55-2, name is 6-Bromo-2-methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H6BrNO

A mixture of 6-chloro-2-methyl-pyridine-3-carbaldehyde (715 mg, 4.60 mmol), methyl 4-hydroxyphenylacetate (694 mg, 4.18 mmol) and K2CO3 (404 mg, 2.92 mmol) in DMF (8.4 mL) was heated to 130 0C for 1 h then filtered and concentrated. The residue was dissolved in EtOAc (40 mL) and washed with brine (3 x 10 mL) then dried (MgSO4) and EPO concentrated. Purification by chromatography on silica gel (30% EtOAc/hexanes) gave [4-(5- formyl-6-methyl-pyridin-2-yloxy)-phenyl]-acetic acid methyl ester as a yellow oil (687 mg, 58%). 1H NMR (CDCl3) delta 2.75 (s, 3H)5 3.66 (s, 2H), 3.73 (s, 3H), 6.76 (d, IH, J= 8.7 Hz), 7.13 (d, 2H, J= 8.7 Hz), 7.34 (d, 2H, J= 8.7 Hz), 8.09 (d, IH, J= 8.4 Hz), 10.24 (s, IH).

With the rapid development of chemical substances, we look forward to future research findings about 926293-55-2.

Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem