In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 94015-05-1, name is 4-Methylnicotinic acid hydrochloride, the common compound, a new synthetic route is introduced below. Quality Control of 4-Methylnicotinic acid hydrochloride
To a solution of 4-methyl nicotinic acid hydrochloride (0.40 g, 2.30 mmol, 1 eq) in DMF dry (4.0 mL), ammonium chloride (0.74 g, 13.90 mmol, 6 eq), HOBt (0.45 g, 3.30 mmol, 1.44 eq), EDCI (0.64 g, 3.30 mmol, 1.44 eq) and N-methylmorpholine (0.63 mL, 5.60 mmol, 2.44 eq) were subsequently added. The reaction was stirred at room temperature, under nitrogen for 3 h. Evaporation of the solvent gave a residue which was purified by column chromatography (neutral alumine oxide, Brockmann grade III) using EtOAc as eluant to give 6 as white solid after crystallization with EtOAc (0.25 g, 79%). Mp. 157-162 C. 1H NMR (300 MHz, CD3OD) delta 8.52 (s, 1-H), 8.43 (d, J = 5.2 Hz, 1-H), 7.34 (d, J = 5.2 Hz, 1-H), 2.49 (s, 3-H); 13C NMR (75 MHz, CD3OD) delta 170.8, 149.6, 146.8, 146.7, 132.9, 126.1, 18.2; GC-MS m/z 136 (M)+; IR (KBr) 3335, 3046, 2800, 1685, 1597, 1430, 1175, 842 cm-1. Anal. Calcd for C7H8N2O: C, 61.75; H, 5.92; N, 20.58. Found: C, 62.10; H, 6.25; N, 20.60.
The synthetic route of 94015-05-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 58 – 66,9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem