Adding a certain compound to certain chemical reactions, such as: 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
A mixture of 5-bromo-3-(difluoromethoxy)pyridine-2-amine (88mg, 0.37 mmol), bis(pinacolato)diboron (102mg, 0.40 mmol), potassium acetate (0.215mg, 2.2 mmol), and Pd(dppf)-CH2C12 (30mg, 0.037mmol) in dry dioxane (2.0 mL) was sparged with argon, and heated at 12O0C for 30 min. After cooling to rt, the reaction mixture was centrifuged and the supernatant decanted, and used in the next step without further purification: LCMS (m/z, MH+, boronic acid): 205.0, R = 0.27min.
The synthetic route of 947249-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; WO2009/115572; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem