Reference of 96630-88-5, Adding some certain compound to certain chemical reactions, such as: 96630-88-5, name is 4-Chloro-3-hydroxypyridine,molecular formula is C5H4ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 96630-88-5.
Step A: Preparation of 4-Chloro-3-methoxypyridine. To a cold solution of 4-chloropyridin-3-ol (200 mg, 1.544 mmol), triphenylphosphine (0.810 g, 3.088 mmol), and MeOH (0.125 mL, 3.088 mmol) in THF (5 mL) was slowly added diisopropyl azodicarboxylate (0.610 mL, 3.088 mmol). The reaction was stirred at room temperature for 1 h. The mixture was concentrated under reduced pressure and the residue was triturated with EtOAc to precipitate triphenylphosphine oxide. The solid was removed by filtration and the filtrate was concentrated under reduced pressure and purified by column chromatography to give the title compound (89.4 mg, 0.623 mmol, 40.3%) (purity was about 58 wt%) as a brown oil. LCMS m/z = 144.2 [M+H]+; lU NMR (500 MHz, CDC13) delta ppm 4.00 (s, 3H), 7.32 (d, J = 5.04 Hz, 1H), 8.17 (d, J = 4.41 Hz, 1H), 8.30 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 96630-88-5, 4-Chloro-3-hydroxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert, M.; BUZARD, Daniel, J.; HAN, Sangdon; KIM, Sun, Hee; LEHMANN, Juerg; WO2012/170702; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem