Electric Literature of 95727-86-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 95727-86-9, name is 5-(Trifluoromethyl)picolinonitrile, molecular formula is C7H3F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The 2-[alpha-(1,2,4-triazolyl)propionyl]-5-trifluoromethylpyridine used as starting material in the above Examples was prepared as follows: To a solution of ethyl magnesium iodide [formed from ethyl iodide (46.8 g.) and magnesium turnings (7.2 g.) in anhydrous ether (250 ml.)], cooled to 0-5, was added a solution of 2-cyano-5-trifluoro-methylpyridine (10.32 g.) in anhydrous ether (50 ml.) during 20 minutes. The resulting grey suspension was stirred at 5 for 30 minutes then poured into a mixture of ice/water/2N hydrochloric acid. After stirring for 15 minutes the mixture was extracted with ether. The organic extract was washed with water, dried over magnesium sulphate and concentrated to dryness under reduced pressure. The residue was purified on a silica column using hexane:ether (9:1 v/v) as eluent, to give 2-propionyl-5-trifluoromethylpyridine as a colourless oil.
According to the analysis of related databases, 95727-86-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Imperial Chemical Industries PLC; US4866086; (1989); A;,
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