Synthetic Route of 6345-27-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6345-27-3 as follows.
3. 2-(4-Pyridinyl)-4-pyrimidinamine – A mixture containing 31.6 g. of isonicotinamidine hydrochloride, 10.8 g. of sodium methoxide and 200 ml. of ethanol was stirred at ambient temperature for 30 minutes and then cooled in a running water bath. To the stirred mixture was added 18 g. of alpha-chloroacrylonitrile dropwise over a period of 25 minutes whereupon the internal temperature arose to 45° C. The reaction mixture was stirred for thirty minutes and then refluxed for two hours. To the reaction mixture was added 13 ml. of 35percent aqueous sodium hydroxide solution and the mixture was cooled. The solid was collected, washed successively with water and ethanol and dried to yield 16.8 g. of 2-(4-pyridinyl)-4-pyrimidinamine, m.p. 261°-263° C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6345-27-3, its application will become more common.
Reference:
Patent; Sterling Drug Inc.; US4109092; (1978); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem