Adding a certain compound to certain chemical reactions, such as: 65515-28-8, Methyl 2,6-dichloronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
A 250 mL eggplant flask was sequentially charged with methyl 2,6-dichloronicotinate (4.12g, 20 mmol), [1,1?-biphenyl]-4-phenol (3.40 g, 20 mmol), and 24 mL of N, N-dimethylformamide for dissolving them. Triethylamine (3.8 mL,26 mmol) was added dropwise under stirring at room temperature, and after completion of the dropwise addition, triethylenediamine (336 mg, 3 mmol) was added. The mixture was stirred at room temperature for 4-5 hours and the solutionchanged from clear to turbid. Thin layer chromatography [V (petroleum ether) / V (ethyl acetate) = 6/1] detected thatmost of the raw material disappeared. Then, 1.30 mL of HOAc, 25 mL of isopropanol and 15 mL of ice water weresequentially added while the solution changed from turbid to clear, and stirred at room temperature for 0.5 hour. 40mLof water was slowly dropwise added, and after completion of the dropwise addition, stirred at room temperature for 2hours. A large number of white solid precipitated and was filtered. The filter cake was washed with a mixed solution ofisopropyl alcohol / water = 1: 1 and dried under vacuum at 50 C for 8 hours to obtain 5.66 g of methyl 6-([1,1?-biphenyl]-4-oxo)-2-chloronicotinate as a solid, 83.24%
The synthetic route of 65515-28-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenyang Sunshine Pharmaceutical Co., Ltd.; ZHOU, Yunlong; CAI, Suixiong; WANG, Guangfeng; JIAO, Lingling; MIN, Ping; JING, Yu; GUO, Ming; (44 pag.)EP3275881; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem