Adding a certain compound to certain chemical reactions, such as: 120739-77-7, N-((6-Chloropyridin-3-yl)methyl)ethanamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 120739-77-7, blongs to pyridine-derivatives compound. category: pyridine-derivatives
1, In the 5000L stainless steel reactor,put disodium hydrogenphosphate 284kg, sodium dihydrogen phosphate, 67.9kg,720kg of tap water was added. Stirred solution becomes clear. At 25 deg.C, then 1500kg of methylene chloride was added, as well as N- (6-chloro – 3-pyridylmethyl) -N- ethylamine 341kg. Cooled 0 deg. C;2, was added dropwise 325 kg of 1,1-dichloro-2-nitroethylene, about 2 ~ 3h, temperature 5 ~ 10 deg.C;3, addition was complete at 5 ~ 10 deg.C. Maintain temperature for 2h; 4, then dropping 40% monomethylamine 390kg,about 2 ~ 3h, and maintain temperature for 2h at 5 ~ 10 deg.C ;5, then heated to 30 deg.C and hold temperature 1h; 6, still 30min, separated and the aqueous layer was further 500kg, extracted once with methylene chloride; 7, the combined organic phases, first at atmospheric pressure and then vacuum recovery methylene chloride, ethyl acetate500kg;8, 0 ~ 5 deg.C cooling crystallization 2h, centrifugal drying drying material, was 494.1kg, HPLC?99.5%,external standard content ?98%, a yield of 0.92.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,120739-77-7, its application will become more common.
Reference:
Patent; Shanghai Jinjing Chemical Co., Ltd.; Long, Congwei; Ma, Jun; Zhou, Xianpei; Tang, Songqing; Lv, Yejun; (9 pag.)CN105330593; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem