Electric Literature of 562825-95-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.562825-95-0, name is N-Ethyl-3-nitropyridin-4-amine, molecular formula is C7H9N3O2, molecular weight is 167.17, as common compound, the synthetic route is as follows.
A mixture of ethyl (3-nitropyridin-4-yl) amine (11.8 g, 70.0 MMOL), acetic acid (140 mL), sodium acetate (28.7 g, 0.35 mol) and bromine (13.4 g, 84.0 MMOL) was stirred in a pressure vessel at 100 C for 18 h. The solvent was removed in vacuo and the residue partitioned between CH2CI2 and water. The aqueous layer was made basic (PH-8) with NAHCO3 and further extracted with CH2CI2. The combined organic extracts were washed with water, brine and dried (NA2SO4). The solvent was removed in vacuo. and the residue subjected to flash chromatography (20% EtOAc/hexanes, silica gel) to give 10.4 g (60%) of the desired compound. MS (ES+) m/z 246 (M+H) +.
The chemical industry reduces the impact on the environment during synthesis 562825-95-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/11700; (2005); A1;,
Pyridine – Wikipedia,
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