In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1594-58-7, name is N-Hydroxynicotinimidamide, the common compound, a new synthetic route is introduced below. Safety of N-Hydroxynicotinimidamide
To a solution of 5-(lH-pyrrol-l-yl)nicotinic acid (Maybridge, 188 mg, 1.00 mmol) in dimethylformamide (anhydrous, 5 mL) was added N-(3-methylaminopropyl)-N’- ethylcarbodiimide hydrochloride (EDC) (Aldrich, 192 mg, 1.00 mmol) and 1- hydroxybenzotriazole (HOBT) hydrate (Fluka, 153 mg, 1.00 mmol). The mixture was stirred at ambient temperature for 20 minutes. lambdaf’-Hydroxynicotinimidamide (137 mg, 1.0 mmol) was added and the mixture was stirred for 6-10 hours, and then warmed to 140 0C for 2-4 hours. The reaction was cooled to ambient temperature and triturated with water (10 mL). The precipitate was filtered and dried under vacuum to give the titled compound. 1H NMR (300 MHz, DMSO-J6) delta 6.34 – 6.44 (m, 2 H), 7.60 – 7.82 (m, 3 H), 8.50 (dt, J=8.1, 1.9 Hz, 1 H), 8.71 (dd, J=2.5, 1.9 Hz, 1 H), 8.84 (dd, J=4.6, 1.5 Hz, 1 H), 9.21 (d, J=1.7 Hz, 1 H), 9.26 (d, J=2.4 Hz, 1 H), 9.31 (d, J=I .7 Hz, 1 H) ppm; MS (DCI/NH3) m/z 290 (M+H)+.
The synthetic route of 1594-58-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; WO2009/148452; (2009); A1;,
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