Reference of 6332-56-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6332-56-5, name is 3-Nitropyridin-2(1H)-one, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.
(14a) 3-Nitro-1-phenyl-1,2-dihydropyridin-2-one 5g of 2-hydroxy-3-nitropyridine, 7.14g of phenylboronic acid, 2.6g of copper (II) acetate, 9.9ml of triethylamine and 5.8ml of pyridine were added to 100ml of tetrahydrofuran, followed by stirring overnight. The reaction mixture was poured into aqueous ammonia, and extracted with ethyl acetate. The organic layer was washed with water, dried, and concentrated. The residue was suspended into ether, and collected by filtration, to give 4.71g of the title compound. 1H-NMR (400MHz, CDCl3); delta(ppm) 6.39(dd, 1H), 7.36-7.40(m, 2H), 7.49-7.54(m, 3H), 7.73(dd, 1H), 8.38(dd, 1H).
Statistics shows that 6332-56-5 is playing an increasingly important role. we look forward to future research findings about 3-Nitropyridin-2(1H)-one.
Reference:
Patent; Eisai Co., Ltd.; EP1300396; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem