With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.152460-10-1, name is N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine, molecular formula is C16H15N5, molecular weight is 277.32, as common compound, the synthetic route is as follows.Safety of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
Embodiment 6 In a 5000 mL dried 4-neck flask, 3000 mL propanol, 277 g 4-methyl-N-3-(4-pyridin-3-yl-pyrimidin-2-yl)-1,3-benzenediamine, and 2250 g 4-(4-methyl-piperazin-1-methyl)-benzoic acid phenyl ester were added. After it was stirred to dissolve, 1500 g cesium hydroxide was then added. The mixture was heated to 80 C. for reaction overnight until the reaction was detected to be complete, and then concentrated to remove propanol. The obtained solid was washed with water and dried, thus 450 g Imatinib was obtained, and the yield is 90.5%. The data of spectrum is the same as above.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,152460-10-1, N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine, and friends who are interested can also refer to it.
Reference:
Patent; Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing; US2013/41149; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem