Synthetic Route of 69214-09-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.69214-09-1, name is 5-Bromoimidazo[1,2-a]pyridine, molecular formula is C7H5BrN2, molecular weight is 197.03, as common compound, the synthetic route is as follows.
Method 33 3-Acetvl-5-bromoimidazo[1,2a]pyridine Aluminium chloride (10.2g, 77mmol) was added in portions over 10 minutes to a solution of 5-bromoimidazo[1,2a]pyridine (Method 32; 5.0g, 26mmol) in dichloromethane (100ml) cooled to 0C. The mixture was heated to reflux and acetyl chloride (2.54ml, 36mmol) was added over 15 minutes. The mixture was heated at reflux for 24 hours, cooled to 0C, and further aluminium chloride (10.2g, 77mmol) followed by acetyl chloride (3.26ml) were added. The mixture heated at reflux for 24 hours and then the volatiles were removed by evaporation. Iced water was added, the mixture was basified with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate. The extracts were washed with water, dried and the solvent evaporated to the title compound which was used without further purification 4.0g. NMR: 2.58 (s, 3H), 7.74-7.82 (m, 2H), 8.62 (s, 1H), 9.62 (s, 1H); m/z: 241 [MH]+
Statistics shows that 69214-09-1 is playing an increasingly important role. we look forward to future research findings about 5-Bromoimidazo[1,2-a]pyridine.
Reference:
Patent; AstraZeneca AB; EP1214318; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem