Synthetic Route of 771579-27-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below.
[01759] The above acid (0.2 g, 0.68 mmol) was then dissolved in DMSO (0.5 mL) and 3- (amino methyl)-4, 6-dimethylpyridin-2(l H)-one (0.206 g, 1 .35 mmol) was added. The reaction mixture was stirred at room temperature for 15 min before PYBOP (0.528 g, 1 .01 mmol) was added t and stirring was continued overnight. The mixture was poured into ice and extraction was carried out using 10 % MeOH/DCM. The combined organic layers were dried over sodium sulphate and concentrated under reduced pressure to obtain crude material which was purified by column chromatography giving the title compound (0.2 g, 69 %). LCMS: 432.25 (M + 1 )+;HPLC: 99.95% ((at) 254 nm) (R,;5.750; Method: Column: YMC ODS-A 1 50 mm x 4.6 mm x 5 mu; Mobile Phase: A; 0.05% TFA in water/ B; 0.05% TFA in acetonitrile; Inj. Vol : ) 0 mu,, Col. Temp.: 30 C; Flow rate: 1 .4 mL/min.; Gradient: 5% B to 95% B in 8 min, Hold for 1.5 min, 9.5 1 – 12 min 5% B); NMR (DMSO- 6, 400 MHz) delta 1 1 .45 (s, 1 H), 8.19 (t, 1 H), 7.10 (d, 1 H, J= 1 .6 Hz), 6.90 (d, 1 H, J=2 Hz), 5.85 (s, 1 H), 4.23 (d, 2H, J=4.8 Hz), 3.80 (d, 2H, J=8.4 Hz), 3.21 -3.27 (m, 2H), 2.73 (d, 2H, J=7.2 Hz), 2.55 (s, 3H), 2.18 (s, 3H), 2.1 5 (s, 3H), 2.10 (s, 3H), 1 .74- 1.75 (m, 1 H), 1 .58- 1.61 (m, 2H), 1.07-1 .16 (m, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,771579-27-2, its application will become more common.
Reference:
Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
Pyridine – Wikipedia,
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