As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 153747-97-8, name is tert-Butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate, molecular formula is C14H20BrN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 153747-97-8
To a stirred solution of tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate (10 g, 29.21 mmol) in 1,4-dioxane (5OmL), 4N HCI solution in dioxane (100 mL, IOV) was added and the mixture was stirred 4 h at rt. The white precipitate formed was filtered and residuewas washed with diethyl ether (25 mL) to afford the title compound. Yield: 95.2% (9 g, off white solid). 1H NMR (400 MHz, DMSO-d6): 6 10.05 (br s, 2H), 8.21 (d, J = 2.4 Hz, IH), 7.82 (dd, J = 9.2, 2.4 Hz, IH), 6.99 (d, J = 9.2 Hz, IH), 3.80-3.77 (m, 4H), 3.33-3.13 (m, 4H). LCMS: (Method A) 243.9 (M +2H), Rt. 1.69 mm, 99.3 % (Max).
With the rapid development of chemical substances, we look forward to future research findings about 153747-97-8.
Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
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