Related Products of 1188477-11-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1188477-11-3, name is tert-Butyl ((5-bromopyridin-2-yl)methyl)carbamate. A new synthetic method of this compound is introduced below.
To a mixture of tert-butyl ((5-bromopyridin-2-yl)methyl)carbamate (2.2 g, 7.7 mmol) in 1,4-dioxone (4 mL) was added a solution of HCl in 1,4-dioxane (20 mL, 60 mmol, 3 M HCl in 1,4-dioxane). The mixture was stirred at 28C for 2 hr then concentrated to dryness to give the crude product (2.2 g crude) as yellow solid which was directly used in the next step without further purification. LC-MS: m/z 186,188 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1188477-11-3, tert-Butyl ((5-bromopyridin-2-yl)methyl)carbamate, and friends who are interested can also refer to it.
Reference:
Patent; SPERO THERAPEUTICS, INC.; ZAHLER, Robert; (262 pag.)WO2016/112088; (2016); A1;,
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