Recently I am researching about TRANSITION-STATE ANALOG; CRYSTAL-STRUCTURE; HYDROXY COMPOUNDS; DERIVATIVES; PYRROLIDINE; BINDING; PHOSPHORYLATION; ENANTIOMERS; MECHANISM; ALCOHOLS, Saw an article supported by the Royal SocietyRoyal Society of LondonEuropean Commission; EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/I000992/1]; University of Surrey, U.K.; Sultanate of Oman; Erasmus+ scheme. Formula: C6H5NO. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde
The DNA repair enzyme AAG has been shown in mice to promote tissue necrosis in response to ischaemic reperfusion or treatment with alkylating agents. A chemical probe inhibitor is required for investigations of the biological mechanism causing this phenomenon and as a lead for drugs that are potentially protective against tissue damage from organ failure and transplantation, and alkylative chemotherapy. Herein, we describe the rationale behind the choice of arylmethylpyrrolidines as appropriate aza-nucleoside mimics for an inhibitor followed by their synthesis and the first use of a microplate-based assay for quantification of their inhibition of AAG. We finally report the discovery of an imidazol-4-ylmethylpyrrolidine as a fragment-sized, weak inhibitor of AAG.
Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem