In 2013,Thomae, David; Jeanty, Matthieu; Coste, Jerome; Guillaumet, Gerald; Suzenet, Franck published 《Extending the Scope of the Aza-Fischer Synthesis of 4- and 6-Azaindoles》.European Journal of Organic Chemistry published the findings.Formula: C5H5BrN2 The information in the text is summarized as follows:
Fischer indole cyclization has recently been described as an efficient approach to the synthesis of azaindoles bearing electron-donating groups. It was reported that this cascade reaction can be very efficient for the formation of a wider range of 4- and 6-azaindoles by using microwave irradiation6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2) was used in this study.
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Formula: C5H5BrN2