The author of 《Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(II) complexes under hypoxic conditions》 were Tian, Na; Sun, Weize; Guo, Xusheng; Lu, Jian; Li, Chao; Hou, Yuanjun; Wang, Xuesong; Zhou, Qianxiong. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. COA of Formula: C12H10Cl2N2 The author mentioned the following in the article:
Three chloromethyl-modified Ru(II) complexes were designed and synthesized as mitochondria targeting photosensitizers, which can generate carbon radicals in the presence of NADH under visible light irradiation, cause DNA cleavage and covalent binding in Ar-saturated solutions, and lead to apoptosis of human ovarian carcinoma SKOV-3 cells under hypoxic conditions (3% O2), demonstrating a new mode of type I mechanism to overcome the limitation of hypoxia in photodynamic therapy (PDT). The results came from multiple reactions, including the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4COA of Formula: C12H10Cl2N2)
4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. COA of Formula: C12H10Cl2N2