Halogen-metal exchange on bromoheterocyclics with substituents containing an acidic proton via formation of a magnesium intermediate was written by Tian, Qingqiang;Shang, Suqin;Wang, Huajun;Shi, Guoqiang;Li, Zhiyao;Yuan, Jianyong. And the article was included in Molecules in 2017.Quality Control of 3,5-Dibromo-2-hydroxypyridine This article mentions the following:
A selective and practical bromine-metal exchange on bromoheterocyclics bearing substituents with an acidic proton under non-cryogenic conditions was developed by a simple modification of an existing protocol. This protocol used a combination of i-PrMgCl and n-BuLi was not only solved the problem of intermol. quenching that often occurred when using alkyl lithium alone as the reagent for halogen-lithium exchange, but also offered a highly selective method for performing bromo-metal exchange on dibrominated arene compounds through chelation effect. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Quality Control of 3,5-Dibromo-2-hydroxypyridine).
3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 3,5-Dibromo-2-hydroxypyridine