《Transition-Metal-Free Coupling Reactions: PPh3-Promoted Sonogashira-Type Cross-Couplings of Heteroaryl Halides with Terminal Alkynes》 was published in ChemistrySelect in 2020. These research results belong to Tian, Wan-Fa; He, Ke-Han; Li, Na; Fen; Liu; Mai, Xi; Feng, Li-Hua; He, Yong-Qin. Name: 2-Bromo-5-methylpyridine The article mentions the following:
Synthesis phenylethynyl heteroaryl I [Ar1 = 2-pyridyl, 6-Me-3-pyridyl, 3-quinolyl, etc.; Ar2 = Ph 2-FC6H4, 4-MeOC6H4, etc.] via Sonogashira-type cross-coupling reaction of heteroaryl halides with terminal alkynes under mild transition-metal-free conditions using PPh3 and Cs2CO3/NEt3 was reported, a wide range of functional groups was tolerated under optimized conditions. Furthermore, the protocol would be extended to the Suzuki-type cross-coupling of heteroaryl halides with phenylboronic acid, to gave the Ph heteroaryl II [Ar3 = 3-pyridyl, 5-pyrimidinyl, 3-quinolyl, etc.] in good to excellent yields. A test reaction on gram scale delivered the product in reasonably high yield and thus had the potential of promising applications in drug discovery and functional materials. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: 2-Bromo-5-methylpyridine