Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N. published the artcile< Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning>, SDS of cas: 22280-62-2, the main research area is fluorinated pyridinealdoxime preparation treatment organophosphorus nerve agent poisoning; sarin poisoning fluorinated pyridinealdoxime preparation treatment.
Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime and 3-fluoropyridine-2- and -4-aldoxime were synthesized. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4-aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pKa nearer to 8 and enhance their therapeutic potential.
Journal of Fluorine Chemistry published new progress about Antidotes. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, SDS of cas: 22280-62-2.