In 2019,Chemical & Pharmaceutical Bulletin included an article by Togo, Takaya; Sohma, Youhei; Kuninobu, Yoichiro; Kanai, Motomu. COA of Formula: C6H6BrN. The article was titled 《Palladium-catalyzed C-H heteroarylation of 2,5-disubstituted imidazoles》. The information in the text is summarized as follows:
A palladium-catalyzed C-H N-heteroarylation of N-protected-2,5-disubstituted imidazoles at the C4-position using N-heteroaryl halides as a coupling partner was developed. Intensive reaction condition screening led to identify fluorinated bathophenanthroline as the optimum ligand for the palladium catalyst. This reaction enhanced optimization of drug candidates by facilitating the synthesis of heterobiaryl compounds containing an imidazole ring. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5COA of Formula: C6H6BrN)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H6BrN