A new synthesis of 3,4-diaminothiophenes was written by Tominaga, Yoshinori;Fujito, Hiroshi;Matsuda, Yoshiro;Kobayashi, Goro. And the article was included in Heterocycles in 1977.SDS of cas: 17281-59-3 This article mentions the following:
Thiophenediamines I (R = CN, CONH2, CO2Et, Bz) were prepared by treating R1CH2CNCl– (R1 = pyridinio) with CS2-NaOH, treating R1C(CN):C(SNa)S– with R2CH2R (R2 = Cl, Br), cyclizing R1C(CN):C(S–)SCH2R with NEt3, methylating ylides II (R3 = S–), treating II (R3 = SMe) with MeNH2-HCl and neutralizing. I condensed with R4COCOR4 (R4 = H, Me, Ph) to give the thienopyrazines III. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3SDS of cas: 17281-59-3).
1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 17281-59-3