Synthesis of 2-methylthioindolizine-3-carbonitriles using nitroketene dithioacetal was written by Tominaga, Yoshinori;Shiroshita, Yoshihide;Hosomi, Akira. And the article was included in Journal of Heterocyclic Chemistry in 1988.Name: 1-(Cyanomethyl)pyridin-1-ium chloride This article mentions the following:
The reaction of 1-cyanomethylpyridinium chloride or bromide, with 1,1-bis(methylthio)-2-nitroethylene in the presence of Et3N in ethanol gave the corresponding 2-methylthioindolizine-3-carbonitrile I (R = H, Ph; R1 = H, Me, Et; R2 = H, Et, Ph, CH2Ph; R3 = H, Me, Et) and 2-methylthio-1-nitroindolizine-3-carbonitrile in good yields, resp. Compounds I (R-R3 = H; R = R2 = H, R1 = R3 = Me) were key intermediates for the synthesis of cycl[3,2,2]azine derivatives In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Name: 1-(Cyanomethyl)pyridin-1-ium chloride).
1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 1-(Cyanomethyl)pyridin-1-ium chloride