Synthesis and reaction of 3,4-diaminothiophenes was written by Tominaga, Yoshinori;Fujito, Hiroshi;Norisue, Hajime;Ushirogochi, Atsuyuki;Matsuda, Yoshiro;Kobayashi, Goro. And the article was included in Yakugaku Zasshi in 1979.SDS of cas: 17281-59-3 This article mentions the following:
Addition of pyridinium chloride I and CS2 gave Ia, which was alkylated by XCH2Y (X = Cl, Br; Y = CN, CO2Et, Bz, CONH2), cyclized, and iodomethylated to give II (R1 = CN, CO2Et, Bz, CONH2; R2 = pyridinio iodide). Cleavage of II iodide by addition of MeNH2 followed by cyclization, acid hydrolysis, and neutralization gave II (R1 = CN, CO2Et, Bz, CONH2; R2 = NH2). Also prepared were thieno[3,2-d]pyrimidinones III (R3 = Me, Ph; R4 = NH2, NHBz, pyridinio chloride) and the thieno[3′,4′:4,5]imidazo[1,2-a]pyridine IV. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3SDS of cas: 17281-59-3).
1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 17281-59-3