Tomita, M. published the artcileComparative responses of the carotid and vertebral arterial systems of rhesus monkeys to betahistine, Recommanded Product: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, the publication is Stroke (1978), 9(4), 382-7, database is CAplus and MEDLINE.
Following i.v. administration of betahistine mesylate (I) [54856-23-4], the mean transit times of blood through the carotid and vertebral arteries were equally shortened by 10%, despite a 20% decrease in the mean arterial blood pressure. The cerebral tissue and cerebellar tissue blood flow was increased by I 70.4-81.4 and 73.2-84.0 mL/100g/min, resp. Since histamine has been reported to produce a decrease in cardiac output, the increase in cerebral blood flow confirmed that I is a selective cerebral vasodilating agent. However, by comparing the hemodynamic data for the 2 cerebral arterial systems, the responses of the carotid and vertebral arterial systems to the vasodilating action of I were essentially the same.
Stroke published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C7H9BO3S, Recommanded Product: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem