The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about Potentially biologically active new substituted anilides of benzo[2,3-b]thiophene series, the main research direction is benzothiophenecarboxamide preparation conformation; nicotinamide preparation conformation.HPLC of Formula: 39901-94-5.
Anilides RCONMeC6H4CO2Me-4 [R = 2-chlorobenzothien-2-yl], RCONHC6H4C(:NH)NH2.HCl (I), R1CONHC6H4CN-4 [R1 = 3-pyridinyl], R1CONHC6H4C(:NH)NH2.HCl, and its methiodide (II), together with the earlier described RCONHC6H4CO2Me-4 (III) and RCONHC6H4CN, were prepared from the heterocyclic carbonyl chlorides and H2NC6H4CO2Me-4 or H2NC6H4CN-4, followed by n-methylation. The Pinner reaction was used in the preparations of amidino-substituted compounds It seems that all the prepared compounds could be biol. interesting, especially amidino-substituted anilides prepared in the form of water-soluble hydrochlorides or hydroiodides. Mol. and crystal structures of I-III were determined by X-ray single-crystal diffractometry in the solid state. I-III are not planar and the amide group (C=O in relation to NH group) is in trans position in all three compounds The 3-chlorobenzo[b]thiophene moiety in I and III is oriented with the chloro substituent in cis position in relation to amide NH group. The conformational characteristics of the compounds result from the introduction of different substituents or solvent mols. (water mol. in III), which leads to various intermol. hydrogen bonds formation (N-H•••O, N-H•••Cl, O-H•••Cl-, N-H•••I-) in I-III. Hydrogen bond formation could be responsible for the potential biol. activity of the compounds
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