Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 4930-98-7, Name is 2-Hydrazinylpyridine, SMILES is NNC1=NC=CC=C1, belongs to pyridine-derivatives compound. In a document, author is Park, Eunsun, introduce the new discover, Recommanded Product: 2-Hydrazinylpyridine.
Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors
Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of N-alkyl-substituted 1-H-pyrrolo[2,3-b] pyridine carboxamide as a JAK1-selective scaffold, and the synthesis of various methyl amide derivatives provided 4- ((cis-1- (4-chlorobenzyl)-2-methylpiperidin-4-yl) amino-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (31g) as a potent JAK1-selective inhibitor. In particular, the (S,S)-enantiomer of 31g (38a) exhibited excellent potency for JAK1 and selectivity over JAK2, JAK3, and TYK2. On investigating the effect of 31g on hepatic fibrosis, it was found that it reduces the proliferation and fibrogenic gene expression of TGF-beta-induced hepatic stellate cells (HSCs). Specifically, 31g significantly inhibited TGF-beta-induced migration of HSCs at 0.25 mu M in wound-healing assays.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4930-98-7 is helpful to your research. Recommanded Product: 2-Hydrazinylpyridine.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem