In 2019,CrystEngComm included an article by Torubaev, Y. V.; Skabitsky, I. V.. Application In Synthesis of 4-Cyanopyridine. The article was titled 《The energy frameworks of Aufbau synthon modules in 4-cyanopyridine co-crystals》. The information in the text is summarized as follows:
The supramol. arrangement of 4-cyanopyridine (4CNpy) in its native crystal form and its co-crystals with halogen bond (XB) donors is discussed in terms of long-range synthon Aufbau modules (LSAMs) and energy frameworks. Dissociations of 2D zigzag chains of parent 4CNpy into 1D dimers observed in its co-crystals are in good agreement with the Aufbau model. Its co-formers, XB donors 1,4-I2(CF2)4, C2I2, 1,3- and 1,4-I2C6F4 (m- and p-DITFB), provide equal energy of I···N XBs, but perfluorinated iodo-alkane 1,4-I2(CF2)4 and diiodoacetylene C2I2 cannot achieve the same strength of homomol. aggregation as π-π stacking in columnar DITFB modules. As a result, DITFBs form I···N XBs with both Npy and NCN nitrogen atoms of 4CNpy, while 1,4-I2(CF2)4 and C2I2 only with the Npy atom. This is not a particular case of 4CNpy co-crystals, but in general, DITFB appears to be a more effective XB donor co-former than C2I2, 1,4-I2(CF2)n and other iodo-XB donors, which has similar potential to an iodine atom but lacks homomol. aggregation. In supramol. reactions of p-DITFB with (η6-Ar)RuX2(4CNpy) (Ar = p-cymene, X = Cl, I) bearing Npy-coordinated 4CNpy, the former gives definite preference to the XBs with the halogen atoms, but not to the CN group of the 4CNpy ligand. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application In Synthesis of 4-Cyanopyridine