Tran, Gael published the artcileBase-Controlled Completely Selective Linear or Branched Rhodium(I)-Catalyzed C-H ortho-Alkylation of Azines without Preactivation, Application of 3-Chloro-4-(trifluoromethyl)pyridine, the main research area is base controlled rhodium catalyzed regioselective alkylation azine acrylate acrylamide; C−H activation; homogeneous catalysis; nitrogen heterocycles; regioselectivity.
A [RhI]/bisphosphine/base catalytic system for the ortho-selective C-H alkylation of azines by acrylates and acrylamides is reported. This catalytic system features an unprecedented complete linear or branched selectivity that is solely dependent on the catalytic base that is used [e.g., 3-(trifluoromethyl)pyridine + N,N-dimethylacrylamide â?linear product I when KOPiv was used as base vs. branched product II when K3PO4 was used under otherwise identical conditions]. Complete branched selectivity is even achieved for Et methacrylate, which enables the introduction of a quaternary carbon center. Excellent functional group compatibility is demonstrated for both linear and branched alkylations. The operational simplicity and broad scope of this transformation allow for rapid access to functionalized azines of direct pharmaceutical and agrochem. relevance.
Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (acrylates and acrylamides). 81565-19-7 belongs to class pyridine-derivatives, name is 3-Chloro-4-(trifluoromethyl)pyridine, and the molecular formula is C6H3ClF3N, Application of 3-Chloro-4-(trifluoromethyl)pyridine.