Application of 53939-30-3In 2015 ,《Modular, Concise, and Efficient Synthesis of Highly Functionalized 5-Fluoropyridazines by a [2 + 1]/[3 + 2]-Cycloaddition Sequence》 appeared in Organic Letters. The author of the article were Tran, Gael; Gomez Pardo, Domingo; Tsuchiya, Tomoki; Hillebrand, Stefan; Vors, Jean-Pierre; Cossy, Janine. The article conveys some information:
An easy access to 5-fluoropyridazines by a [2+1]/[3+2]-cycloaddition sequence between terminal alkynes, a difluorocarbene, and a diazo compound is reported. This approach does not necessitate the isolation of any intermediates, and a wide range of novel 5-fluoropyridazines, e.g., I (R1 = Ph, 2-MeOC6H4, cyclopropyl, etc., R2 = Et, PhCH2, Me3C), was synthesized from readily available starting materials. Addnl., these compounds were used as a platform to access novel and highly diversified pyridazines. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3Application of 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 53939-30-3