Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG) was written by Tsagris, Denise J.;Birchall, Kristian;Bouloc, Nathalie;Large, Jonathan M.;Merritt, Andy;Smiljanic-Hurley, Ela;Wheldon, Mary;Ansell, Keith H.;Kettleborough, Catherine;Whalley, David;Stewart, Lindsay B.;Bowyer, Paul W.;Baker, David A.;Osborne, Simon A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Product Details of 214834-18-1 This article mentions the following:
A series of trisubstituted thiazoles have been identified as potent inhibitors of Plasmodium falciparum (Pf) cGMP-dependent protein kinase (PfPKG) through template hopping from known Eimeria PKG (EtPKG) inhibitors. The thiazole series has yielded compounds with improved potency, kinase selectivity and good in vitro ADME properties. These compounds could be useful tools in the development of new anti-malarial drugs in the fight against drug resistant malaria. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Product Details of 214834-18-1).
tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Product Details of 214834-18-1