Recommanded Product: Methyl 5-bromopicolinateIn 2012 ,《Synthesis of Highly Oxidized Quinolizidine via Reduction of Acylpyridinium Cations, and Total Syntheses of Quinolizidines 207I and 1-epi-207I》 appeared in Organic Letters. The author of the article were Tsukano, Chihiro; Oimura, Atsuko; Enkhtaivan, Iderbat; Takemoto, Yoshiji. The article conveys some information:
A new strategy for synthesizing quinolizidine skeletons by reductive cyclization via acylpyridinium cations was developed. Several functional groups, including carbonyl, silyl, and acetal, were tolerated under mild reaction conditions. For example, reacting the acylpyridinium cations derived from I (R = Me, Ph, Br, CF3) with Ghosez’s reagent and Hantzch ester in the presence of 4Å mol. sieves gave quinolizidines II. The reaction was successfully extended to a one-pot synthesis of a bicyclic compound, and the synthetic strategy was applied to concise total syntheses of quinolizidines 207I and 1-epi-207I, without protecting groups. The experimental part of the paper was very detailed, including the reaction process of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: Methyl 5-bromopicolinate