《Chemoselective Synthesis of 1,1-Disubstituted Vinyl Triflates from Terminal Alkynes Using TfOH in the Presence of TMSN3》 was written by Tummatorn, Jumreang; Punjajom, Kunlayanee; Rodphon, Warabhorn; Ruengsangtongkul, Sureeporn; Chaisan, Nattawadee; Lumyong, Kanyapat; Thongsornkleeb, Charnsak; Nimnual, Phongprapan; Ruchirawat, Somsak. Quality Control of 4-EthynylpyridineThis research focused onvinyl triflate regioselective chemoselective preparation; terminal alkyne regioselective chemoselective triflation triflic acid silyl azide; hydrazoic acid generated triflation toxic explosive. The article conveys some information:
1,1-Disubstituted vinyl triflates were prepared chemoselectively and regioselectively by direct hydrotriflation of terminal alkynes with TfOH and TMSN3 in DCM at room temperature; internal alkynes did not react under these conditions. Aryl alkynes with both terminal and internal alkyne moieties reacted only at their terminal alkyne moieties. Hydrazoic acid generated in situ in the triflation reaction is toxic and potentially explosive; the reactions should be performed in a well-ventilated fume hood.4-Ethynylpyridine(cas: 2510-22-7Quality Control of 4-Ethynylpyridine) was used in this study.
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of 4-Ethynylpyridine