In 2017,Tung, Truong Thanh; Jakobsen, Tim Holm; Dao, Trong Tuan; Fuglsang, Anja Thoe; Givskov, Michael; Christensen, Soeren Broegger; Nielsen, John published 《Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors》.European Journal of Medicinal Chemistry published the findings.Product Details of 29682-15-3 The information in the text is summarized as follows:
Taking advantage of microwave-assisted synthesis, efficient and expedite procedures for preparation of a library of fusaric acid and 39 analogs are reported. The fusaric acid analogs were tested in cell-based screening assays for inhibition of the las and rhl quorum sensing system in Pseudomonas aeruginosa and the lux quorum sensing system in Vibrio fischeri. Eight of the 40 compounds in the library including fusaric acid inhibited lux quorum sensing and one compound inhibited activity of the las quorum sensing system. To the authors’ delight, none of the compounds showed growth inhibitory effects in the tested concentration ranges. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Product Details of 29682-15-3)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 29682-15-3