《Determination of the complexation parameters of L-asparagine with some biologically active pyridine derivatives in aqueous solutions from calorimetric results》 was published in Thermochimica Acta in 2020. These research results belong to Tyunina, Elena Yu.; Krutova, Olga N.; Lytkin, Alexandr I.. Name: Picolinic acid The article mentions the following:
Thermodn. functions (lgK, ΔcG, ΔcH, ΔcS) were determined by solution calorimetry for the complex formation process of L-asparagine in its zwitterionic form with pharmacol. active ligands, such as pyridoxine, nicotinic acid, isonicotinic acid and picolinic acid in aqueous solutions at 298.15 K. It was found that the complexation affinity of L-asparagine to the pyridine derivatives follows the order picolinic acid < isonicotinic acid < nicotinic acid < pyridoxine. The influence of the presence of hydrophilic substitutes and isomerism of ligands on the stability of amino acid complexes and their thermodn. quantities was discussed. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Name: Picolinic acid)
Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Name: Picolinic acid