Ungwitayatorn, Jiraporn; Wiwat, Chanpen; Matayatsuk, Chutima; Pimthon, Jutarat; Piyaviriyakul, Suratsawadee published the artcile< Synthesis and HIV-1 reverse transcriptase inhibitory activity of non-nucleoside phthalimide derivatives>, Quality Control of 56622-54-9, the main research area is phthalimide nonnucleoside derivative preparation HIV1 reverse transcriptase inhibitory activity.
A new type of non-nucleoside HIV-1 reverse transcriptase inhibitor in the phthalimide series has been synthesized from either the reaction of N-carboethoxyphthalimide with amines or phthalimide with appropriate alkyl halides. The in vitro inhibitory activity of the synthesized compounds was studied by a radiometric assay at a concentration of 200 μg/mL using poly(rA)•oligo(dT) as a template-primer and methyl-[3H]dTTP as a substrate. The three most potent compounds, I-III, exhibited IC50 values of 60.90, 98.10 and 120.75 μg/mL, resp., lower than the IC50 of delavirdine (502.22 μg/mL, using poly(rA)•oligo(dT) as a template-primer and [3H]dTTP as a substrate).
Chinese Journal of Chemistry published new progress about Cyclic imides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Quality Control of 56622-54-9.