Category: pyridine-derivativesIn 2022 ,《Effects of 3-Pyridinylboronic acid in zebrafish enmbryos exposed to neurotoxin,1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine》 appeared in Drug and Chemical Toxicology (1977). The author of the article were Ustundag, Fumet Duygu; Unal, Ismail; Cansiz, Derya; Ustundag, Unsal Veli; Subasat, Hulya Kara; Alturfan, A. Ata; Tiber, Pinar Mega; Emekli-Alturfan, Ebru. The article conveys some information:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism to investigate the mol. pathways in the pathogenesis of Parkinson disease and also for potential therapeutic agent research. Boron has been shown to play an important role in the neural activity of the brain. Boronic acids are used in combinatorial approaches in drug design and discovery. The effect of 3-pyridinylboronic acid which is an important sub-class of heterocyclic boronic acids has not been evaluated in case of MPTP exposure in zebrafish embryos. Accordingly, this study was designed to investigate the effects of 3-pyridinylboronic acid on MPTP exposed zebrafish embryos focusing on the mol. pathways related to neurodegeneration and apoptosis by RT-PCR. Zebrafish embryos were exposed to MPTP (800μM); MPTP + Low Dose 3-Pyridinylboronic acid (50μM) (MPTP + LB) and MPTP + High Dose 3-Pyridinylboronic acid (100μM) (MPTP + HB) in well plates for 72 h post fertilization. Results of our study showed that MPTP induced a P53 dependent and Bax mediated apoptosis in zebrafish embryos and 3-pyridinylboronic acid restored the locomotor activity and gene expressions related to mitochondrial dysfunction and oxidative stress due to the deleterious effects of MPTP, in a dose-dependent manner. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Category: pyridine-derivatives)
Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: pyridine-derivatives